There are 2 routes to the Huai Kha Khaeng reserve: First route is to enter through the reserve headquarters that is around 102 kilometres from the province. Take the Uthai Thani-Nong Chang road Highway No. 333 past Amphoe Nong Chang to Highway No. 3438 Nong Chang-Lan Sak to Km. 53-54, then turn left onto a laterite road for about 14 kilometres.
Access to the Thungyai reserve is harder, as the roads are poor. Take the route Thong Pha Phum-Sangkhla Buri near Huai Suea to Khli Ti Village, a distance of 42 km. After that, there is an intersection leading to the Wildlife Sanctuary Headquarters at Huai Song Thai another 40 km.
